Opdivo (Nivolumab ) Cancer Treatment

What is nivolumab?

Nivolumab, commonly known under the trade name OpdivoÒ, is a substance that belongs to the class of anticancer drugs called monoclonal antibodies. It is mainly used for the treatment of patients with advanced melanoma (not resectable or metastatic) in adults, alone or in association with hypilimumab.

It is indicated for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after previous chemotherapy in adults. OPDIVO is also indicated in monotherapy for the treatment of advanced renal cell carcinoma after previous therapy in adults. OPDIVO is finally used for the treatment of adult patients with recurrent or refractory classical Hodgkin’s lymphoma (cHL) after autologous stem cell transplantation (ASCT) and treatment with brentuximab vedotin.

What is the principle of action

Monoclonal antibodies are synthetic substances, produced in the laboratory, capable of destroying certain types of cancer cells while minimizing damage to healthy cells. Their function is to recognize certain proteins (receptors) present on the surface of certain cancer cells. When the monoclonal antibody detects the presence of the receptor on the surface of the cancer cell, it engages there (like a key that fits into the lock: each key can only fit into one lock).

In this way, it stimulates the body’s immune system to attack the neoplastic cells and may also cause them to self-destruct, or it blocks the receptor by preventing it from binding to a different protein that stimulates the growth of neoplastic cells. As a result, not only are cancer cells no longer able to grow and proliferate, but new blood vessels that feed the tumor cannot be formed. As the supply of oxygen and nutrients is thus lacking, the tumour ‘starves’, and as a result it shrinks or at least stops growing.

RFK speech regarding the assassination of Martin Luther King , Jr, Indianapolis , Indiana

Senator Robert F. Kennedy
Indianapolis, Indiana
April 4, 1968

Kennedy’s speech that night was a plea for compassion and a rallying cry against the spiral of enmity and violence that had torn at the country for much of that decade,
In that night the city of Indianapolis remained calm and safe regarding the threats of violence and revenge

I have bad news for you, for all of our fellow citizens, and people who love peace all over the world, and that is that Martin Luther King was shot and killed tonight.

Martin Luther King dedicated his life to love and to justice for his fellow human beings, and he died because of that effort.

In this difficult day, in this difficult time for the United States, it is perhaps well to ask what kind of a nation we are and what direction we want to move in. For those of you who are black–considering the evidence there evidently is that there were white people who were responsible–you can be filled with bitterness, with hatred, and a desire for revenge. We can move in that direction as a country, in great polarization–black people amongst black, white people amongst white, filled with hatred toward one another.

Or we can make an effort, as Martin Luther King did, to understand and to comprehend, and to replace that violence, that stain of bloodshed that has spread across our land, with an effort to understand with compassion and love.

For those of you who are black and are tempted to be filled with hatred and distrust at the injustice of such an act, against all white people, I can only say that I feel in my own heart the same kind of feeling. I had a member of my family killed, but he was killed by a white man. But we have to make an effort in the United States, we have to make an effort to understand, to go beyond these rather difficult times.

My favorite poet was Aeschylus. He wrote: “In our sleep, pain which cannot forget falls drop by drop upon the heart until, in our own despair, against our will, comes wisdom through the awful grace of God.”

What we need in the United States is not division; what we need in the United States is not hatred; what we need in the United States is not violence or lawlessness; but love and wisdom, and compassion toward one another, and a feeling of justice toward those who still suffer within our country, whether they be white or they be black.

So I shall ask you tonight to return home, to say a prayer for the family of Martin Luther King, that’s true, but more importantly to say a prayer for our own country, which all of us love–a prayer for understanding and that compassion of which I spoke.

We can do well in this country. We will have difficult times; we’ve had difficult times in the past; we will have difficult times in the future. It is not the end of violence; it is not the end of lawlessness; it is not the end of disorder.

But the vast majority of white people and the vast majority of black people in this country want to live together, want to improve the quality of our life, and want justice for all human beings who abide in our land.

Let us dedicate ourselves to what the Greeks wrote so many years ago: to tame the savageness of man and make gentle the life of this world.

Let us dedicate ourselves to that, and say a prayer for our country and for our people.

CAR-T Cell Therapy : a new treatment to Fight Cancer

The therapy I’m referring to is called CAR T cell therapy.
The medicines authority approved it, the FDA in 2017 and 2018, by the European Medicines Agency EMA.
Lymphomas are neoplasms of the immune system.
The most frequent are so-called non-Hodgkin’s lymphomas, most of which are derived from cells called B cells. These are the cells that, in a normal situation, produce the antibodies that defend us from viruses and bacteria, and that circulate undisturbed in the blood, stopping in the marrow, spleen, and lymph nodes as needed by the body.
Lymph nodes are generally the first to be affected when these cells grow uncontrolled, producing a neoplastic process, and typically, the patient arrives with lymphoma comes to the doctor’s attention because he notices an enlarged lymph node.
The only biopsy can confirm the diagnosis and distinguish between the more than 50 histological types.
The chimeric antigen receptor T cells (CAR T cells) are cells of the immune system (T cells, which defend us from infections.
The cells are taken from the patient’s blood, modified in the laboratory, and then reinserted through a small venous catheter, hoping that they find cancer cells and, by activating and multiplying, destroy them.
This type of immunotherapy will undoubtedly revolutionize the way we treat cancer in the future.
Even if 70-80% of patients respond to the therapy, i.e., the lymph nodes begin to fade, the symptoms to soften, the mood to improve, unfortunately, only 45-50% have a prolonged response that continues for at least one year.

1984

When I wrote this book, 📚 I understood this … man is born of reproduces and dies … applies to all … the mind is regenerated and learns through the emotions and experiences made during a lifetime, which can be passed down through generations with the sole task of being saved, progressing themselves and possibly others, understanding what is right and wrong, and avoiding falling into problems … The human mind can be conditioned and sometimes forced to do certain things without knowing The next consequences before they act … this happens to those who live in a constant habitat of ignorance and wickedness wanted or not … in the century to come this will happen, with the media and the media … will teach you an education based on the submission of others, the power of the rich on the poor, the old on the young and so on … creating such a chain and confusion that it is impossible to dislocate … those who behave differently while using reason and common sense will remain in the minority, creating a social and economic disparity … those who understand this will use this tool to command and go to power by manipulating the masses … I, JFK, RFK, MLK, Malcolm X, and I have tried to tell you the truth … that uncomfortable truth that brings wickedness and judgment that cannot be expressed … the will be repressed in a world of hypocrisy and falsehood … a life destined not to be lived because it is imprisoned in past dictatorships always present today

( GEORGE ORWELL 1949)

Gypsy Soul

Someone who posesses a gypsy soul is a person always need of change and /or adventure . A gypsy soul seeks the next best thing in any life situation. They can be very passionate and often inspired by different ideas, attitudes and experience. Their sense of identity isn’t always sure of what they want out of life but they are determined to find it .

Believe

Investors believe it or not. Weather your friends believe it or not, Weather your parents believe it or not.That’s not important to you believe it, your team believe it and work day and night on this.That’s how things happen.Make enough mistake .you fall. stand up. any mistake is an income.its a wonder full revenue. Don’t worry about money. Money follows people.People should follow their dreams, just go ahead. I think nobody conquer the world. We can only serve the world.#letsdoit

Combating Cancer

The researchers have not yet officially found a solution to cancer because many of them depend on pharmaceutical companies for their good and their livelihood. Many people are not aware that disease does not have a viable solution because pharmaceutical companies tend to focus their research on cancer treatment methods to generate the best possible revenue for their business.
Patients diagnosed with cancer are often prescribed treatment involving surgery, radiotherapy, or chemotherapy. Chemotherapy is expensive, and therefore beneficial for pharmaceutical companies that provide facilities and equipment for this type of treatment. To treat cancer, chemotherapy kills cancer cells through the use of powerful chemicals. Patients are very aware of the many side effects of chemotherapy. Perhaps the best known is hair loss. Another is the general feeling of nausea that therapy induces in patients. Depression is another side effect of chemotherapy application to treat cancer.
When the patient is depressed, the effects of depression affect his body in a negative way. This is called the psychosomatic impact, which has been replicated correctly in psychological studies and real-world experiments. Depression causes worse physical conditions, particularly damage to the immune system. The immune system is responsible for fighting cancer cells. When immunity is compromised, it is only a matter of time before the bad cells take over the functional cells. These are often the circumstances that cause the tumor to return after a so-called remission. To better understand cancer as a disease, it is essential to know what cancer cells are and how these cells behave within the human body. A manager at a 7-Eleven store in Vancouver, Canada, believes that cancer cells exist in virtually every human body. The fact that a person smokes does not necessarily mean that he will get cancer sooner or later. It just means that smoking predisposes them. Theoretically, in addition to smoking, there are other risk factors: type of diet, low water intake, hygiene and beauty products, too sedentary lifestyle. In short, a possible solution would be to keep the immune system healthy so that it can continue to fight cancer cells.
Returning to cancer treatment, Signs of the Times reports that “scientists have found the cure for cancer, but no one takes note.” We say the article published as far back as May 15, 2011. “Researchers at the University of Alberta, in Edmonton, Canada, have found a cure for cancer, but it is ignored by the media. It is a simple technique that uses a straightforward drug. The method uses dichloroacetate, a substance that is currently used to treat metabolic disorders. Therefore, there is no concern for side effects or long-term effects. This drug does not require a patent, so anyone can use it widely, and it is cheap compared to expensive cancer drugs produced by large pharmaceutical companies. The drug is publicly available, and the technique is easy to use because large pharmaceutical companies are not involved? Why aren’t the media interested in this discovery? In short, a cure has already been found, but no one is happy about it. The article continues, “However, finding the treatment does not mean that all cancer research should stop. On the contrary, it is in the interest of science to continue to rigorously pursue studies on the subject. Canadian scientists have tested this dichloroacetate (DCA) on human cells and have found that diseased cells in the lungs, breast, and brain have been killed, leaving only the healthy cells.
In the human body, there is a natural element of the human cell, the mitochondria, which can fight a tumor but need to be triggered to be effective. Scientists have realized that these mitochondria cells have been damaged and, therefore, ineffective against cancer and have ended up focusing on glycolysis, which is less effective and more expensive. Drug manufacturers have focused on the method of glycolysis to combat the disease. This DCA is not based on glycolysis, but on the mitochondria, mitochondria are grafted, which in turn fight cancer cells. The side effect of this is that a process called apoptosis is also reactivated. Pharmaceutical companies do not invest in this research because the DCA method cannot be patented; without a patent, they cannot make money, as they are doing now with their AIDS patent. Since pharmaceutical companies will not develop this product,” the article continues, “other independent laboratories should begin to produce this drug and do further research to confirm all the conclusions of that research. Everything can be done in collaboration with universities, which will be happy to assist in this type of research that can develop an effective drug to treat cancer.
Unfortunately, in the light of this further boycott of simple care systems, it seems clear at this point that the medical industry will never find a cure for cancer. Why is that? Because there is too much money going on in this area. Unfortunately, the so-called “best” existing treatment, the costly and devastating chemotherapy, does not work and can even make the tumor worse. The intent of this article is to raise public awareness and the medical environment about this Canadian study, without detracting from the efforts made by many serious researchers, to verify its effectiveness and undertake a spread of the drug.

The banking Act of 1933

Also know as Glass-Steagall , the Banking Act of 1933 effectively separated risky speculative investment banking from traditional . The repeal of this law by Bill Clinton in 1999 led directly to the toxic mortgage – fueled meltdown of 2008.. the root cause of our current economic situation.

Some critics , such Nobel laureate Joseph Stigliz , have long seen the changes of Glass – Steagall as a major factor in 2008 crash. By bringing “investment and commercial banks together , the investment bank culture came out on top”, Stigliz wrote in 2009.

So we can start with this

Lesson number 1

Any mistake it’s a wonderful revenue for you . I told to my young people .

“When you are 20 to 30 years old, you should follow a good boss [and] join a good company to learn how to do things properly,” Ma said.

“When you are 30 to 40 years old, if you want to do something yourself, just do it. You still can afford to lose, to fail,”

when you’re 40 to 50 years old, my suggestion is you should do things you are good at.”

“When you are 50 to 60 years old, spend time training and developing young people, the next generation,”  “When you are over 60 years old, you better stay with your grandchildren.”

 

“You learn from mistakes not because you will be able to avoid mistakes when these mistakes come, [when] these suffers come, you learn how to deal with it, how to face it.”