Opdivo (Nivolumab ) Cancer Treatment

What is nivolumab?

Nivolumab, commonly known under the trade name OpdivoÒ, is a substance that belongs to the class of anticancer drugs called monoclonal antibodies. It is mainly used for the treatment of patients with advanced melanoma (not resectable or metastatic) in adults, alone or in association with hypilimumab.

It is indicated for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after previous chemotherapy in adults. OPDIVO is also indicated in monotherapy for the treatment of advanced renal cell carcinoma after previous therapy in adults. OPDIVO is finally used for the treatment of adult patients with recurrent or refractory classical Hodgkin’s lymphoma (cHL) after autologous stem cell transplantation (ASCT) and treatment with brentuximab vedotin.

What is the principle of action

Monoclonal antibodies are synthetic substances, produced in the laboratory, capable of destroying certain types of cancer cells while minimizing damage to healthy cells. Their function is to recognize certain proteins (receptors) present on the surface of certain cancer cells. When the monoclonal antibody detects the presence of the receptor on the surface of the cancer cell, it engages there (like a key that fits into the lock: each key can only fit into one lock).

In this way, it stimulates the body’s immune system to attack the neoplastic cells and may also cause them to self-destruct, or it blocks the receptor by preventing it from binding to a different protein that stimulates the growth of neoplastic cells. As a result, not only are cancer cells no longer able to grow and proliferate, but new blood vessels that feed the tumor cannot be formed. As the supply of oxygen and nutrients is thus lacking, the tumour ‘starves’, and as a result it shrinks or at least stops growing.

Autore: Fabio Iacobini

Cogito Ergo Sum I am a young man with plenty of determination and motivation. After high school in my village, I decided to move to the university of law in Sassari. After two years, I realized that it was not for me, and I went to London to improve my English and make a new job and life experience. It was great working in the best hotels and restaurants in Central London (Mayfair and Knightsbridge ). I started reading a lot making myself curious about the World and the People. Journalism, soon became my passion for sharing my idea and knowledge to the most famous and richest customers in London. I come back to Italy to spread my knowledge to my family and friends. For the next future, I see my self successful Blogging and in Hospitality with the passion of theatre. I hope to meet all of you, signing an autograph and shaking hands-off in a sign of respect. All the best of luck Yours, Fabio


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